Shukla, Gaurav and Saha , Priya and Pali , Pragya and Raghuvanshi , Keshav and Singh, Maya Shankar (2021) Electrochemical Synthesis of 1,2,3-Thiadiazoles from α‑Phenylhydrazones. Journal of Organic Chemistry , 86 (24). pp. 18004-18016.

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Abstract

We have developed an electrochemical approach for the synthesis of fully substituted 1,2,3-thiadiazoles from α-phenylhydrazones at room temperature, which is very challenging and complementary to the conventional thermal reactions. The key step involves anodic oxidation of phenylhydrazone derivatives at a constant current followed by N,S-heterocyclization. The protocol is remarkable in that it is free of a base and free of an external oxidant and can be converted to a gram scale for postsynthetic drug development with functional thiadiazoles. Most importantly, the electrochemical transformation reflected efficient electro-oxidation with an operationally friendly easy procedure with ample functional molecules. Cyclic voltammograms support the mechanism of this electro-oxidative cyclization process.

Item Type:	Article
Subjects:	Calibration Cell
Divisions:	UNSPECIFIED
Depositing User:	Mr. B. R. Panduranga
Date Deposited:	12 Mar 2026 10:30
Last Modified:	12 Mar 2026 10:30
URI:	https://cimfr.csircentral.net/id/eprint/2948

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