Rathore, Sudarshan Singh (2022) A holistic review on Cryptococcus neoformans. Microbial Pathogenesis, 166.

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Abstract

Cryptococcus neoformans is an encapsulated fungal pathogen that causes infection in immunocompromised individuals such as HIV patients, organ transplant patients, hematological malignancies, diabetes patients, etc. The most common invasive fungal pathogens are Candida spp., Aspergillus spp., and Cryptococcus spp. Cryptococcal meningitis has become increasingly common in immunocompromised patients resulting in a death rate of up to 90%. In low-income and middle-income countries, C. neoformans is a neglected killer in most parts of the world. It has unique and complicated virulence factors that facilitate its intracellular survival and dissemination. The initial infection, latency, or dissemination of the pathogen is determined by its specific morphological features such as capsule size, melanin pigment, biofilm development, etc. In this review, we discussed the worldwide distribution, classification of Cryptococcus spp., and a major focus on the pathogen's strategies that allow it to survive, proliferate subsequently disseminate resulting in cellular damage and treatment.

Item Type:	Article
Uncontrolled Keywords:	Cryptococcus neoformansOpportunistic infectionsHost-pathogen interactionVirulence factorsAnti fungal agents
Subjects:	Chemicals and Liquid Fuels
Divisions:	UNSPECIFIED
Depositing User:	Mr. B. R. Panduranga
Date Deposited:	17 Sep 2025 04:37
Last Modified:	17 Sep 2025 04:37
URI:	http://cimfr.csircentral.net/id/eprint/2892

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