Rathore, Sudarshan Singh (2023) Elucidation of furanone as ergosterol pathway inhibitor in Cryptococcus neoformans. Journal of Biomolecular Structure and Dynamics .

Full text not available from this repository.

Abstract

In the era of antiretroviral therapy, the prevalence of Cryptococcal infection among HIV patients in developed countries has decreased considerably. However, C. neoformans ranks top among the critical priority pathogen that affects a wide range of immunocompromised individuals. The threat of C. neoformans is because of its incredibly multifaceted intracellular survival capabilities. Cell membrane sterols especially ergosterol and enzymes of its biosynthetic pathway are considered fascinating drug targets because of their structural stability. In this study, the ergosterol biosynthetic enzymes were modeled and docked with furanone derivatives. Among the tested ligands Compound 6 has shown a potential interaction with Lanosterol 14 α-demethylase. This best-docked protein-ligand complex was taken further to molecular dynamics simulation. In addition, Compound 6 was synthesized and an in vitro study was conducted to quantify the ergosterol in Compound 6 treated cells. Altogether the computational and in vitro study demonstrates that Compound 6 has anticryptococcal activity by targeting the biosynthetic pathway of ergosterol. Communicated by Ramaswamy H. Sarma

Item Type:	Article
Uncontrolled Keywords:	Cryptococcus neoformans; MD simulation; antifungal agents; docking; ergosterol
Subjects:	Coal Characterisation
Divisions:	UNSPECIFIED
Depositing User:	Mr. B. R. Panduranga
Date Deposited:	29 May 2024 09:09
Last Modified:	29 May 2024 09:09
URI:	http://cimfr.csircentral.net/id/eprint/2738

Actions (login required)

View Item